Ole Nørregaard Jensen

This study uses ion mobility and mass spectrometry imaging to identify distinct ganglioside isomers in Niemann-Pick Disease, showing therapeutic effects of gene therapy on lipid localization.

This study uses multimodal mass spectrometry to accurately map co-occurring histone modifications on intact proteins, enabling residue-level assignment of modifications and positional isomers.

This paper introduces Arg-C Zero, a high-fidelity protease with near-zero missed cleavages, demonstrating its utility in proteomics, especially for analyzing post-translational modifications.

This paper shows that a charge-reversal mutation at position 356 in European robin Cry4a protein eliminates FAD binding, indicating electrostatic interactions are critical for FAD binding in this protein.

The paper evaluates batch correction methods for MALDI mass spectrometry imaging and finds that ComBAT reduces technical variance while preserving biological variation.

The paper identifies PAF15-PCNA assembly as a rate-limiting factor for lagging strand replication and replisome integrity, showing its regulation by the S-phase checkpoint.

This paper evaluates ion mobility spectrometry for resolving isomeric acyl-lysine modifications on histone peptides, showing improved separation with cyclic IMS and revealing structure-mobility relationships.

The paper identifies challenges in validating isobaric histone peptidoforms using mass spectrometry and proposes strategies to improve their identification.

The paper investigates whether ErCry4b in European robins can function as a radical pair magnetic sensor, finding it lacks FAD binding and is not expressed at detectable levels.

The paper introduces a graph-based method to annotate internal fragment ions in tandem mass spectra, improving proteoform sequencing and modification localization.

Anubis authenticates ancient proteins using deamidation patterns and random forest classification, demonstrating reliability with ancient and degraded beta-lactoglobulin.

The paper shows MYC enhances cancer-specific gene programs by inducing an epigenetic switch that promotes RNAPII recruitment to enhancers.

FLASHIda improves proteoform identification in top-down proteomics by intelligently selecting precursors, doubling identification counts in E. coli lysates.

PolySTest improves proteomics data analysis by detecting differentially regulated proteins with missing values, increasing confidence and sensitivity in muscle differentiation studies.

The paper introduces PTM-CrossTalkMapper, a tool to visualize histone PTM dynamics and crosstalk across experimental conditions, showing its application in mouse aging studies.