Maria Szomek

Host-derived lipids license proliferation of sterol-auxotrophic tick cells and promote flavivirus output

This study shows host-derived lipids are essential for tick cell proliferation and flavivirus output, revealing their role in regulating cellular state and viral production.

Live-cell imaging and lipidomics of low density lipoprotein containing intrinsically fluorescent cholesteryl esters

This study uses live-cell imaging and lipidomics to track LDL-derived cholesteryl esters in cells, revealing their transport and metabolism kinetics.

Structural and biochemical analysis of ligand binding in yeast Niemann-Pick type C1-related protein

This study investigates the lipid binding properties of the yeast NCR1/NPC2 system using crystal structures and binding assays, revealing its ability to bind multiple lipids beyond sterols.

Ratiometric fluorescence nanoscopy and lifetime imaging of novel Nile Red analogs for analysis of membrane packing in living cells

This study evaluates modified Nile Red dyes for super-resolution imaging of membrane packing in cells, finding differences in membrane structure between healthy and NPC1 disease fibroblasts.

Automated quantification of lipophagy in Saccharomyces cerevisiae from fluorescence and cryo-soft X-ray microscopy data using deep learning

The paper develops a deep learning method to quantify lipophagy in yeast using fluorescence and cryo-soft X-ray microscopy data.

Analysis of cholesterol export from endo-lysosomes by Niemann Pick C2 protein using combined fluorescence and X-ray microscopy

This study uses fluorescence and X-ray microscopy to show NPC2 facilitates cholesterol export from endo-lysosomes, altering membrane trafficking and organelle structure.