Ivan Trujillo‐Pisanty

Optogenetic stimulation of nigral astrocytes is neuroprotective in a 6-OHDA model of neurodegeneration.

This study shows optogenetic stimulation of nigral astrocytes reduces motor deficits and dopamine neuron loss in a 6-OHDA model of Parkinson's disease.

Does phasic dopamine release cause policy updates?

This study challenges the idea that phasic dopamine release directly causes policy updates by showing stable work rates in rats despite repeated dopamine stimulation.

Relative salience signaling within a thalamo-orbitofrontal circuit governs learning rate

The paper shows that vmOFC neurons signal relative reward salience, influencing learning rate through thalamic inputs in mice.

Drug self-administration in head-restrained mice for simultaneous multiphoton imaging

This paper describes a new experimental assay allowing mice to self-administer drugs while head-restrained, enabling simultaneous multiphoton imaging of neural activity during drug use and relapse.

The effect of dopamine transporter blockade on optical self-stimulation: behavioral and computational evidence for parallel processing in brain reward circuitry

The paper investigates how dopamine transporter blockade affects reward-seeking behavior in rats using optical stimulation, finding differential effects that suggest parallel reward pathways.

Divergent mesolimbic dopamine circuits support alcohol-seeking triggered by discrete cues and contexts

The paper shows that different mesolimbic dopamine circuits mediate alcohol-seeking in response to discrete cues versus contextual cues.