Peter W. Kalivas

This paper expands the RatGTEx resource with transcriptome-wide associations across 3,160 RNA-seq samples, identifying 7,473 gene-trait links and 144,876 QTLs for 22,599 genes.

The paper uses Genomic SEM to identify loci underlying locomotor activity in rats, finding 31 loci compared to fewer from other methods.

This study shows that oral Actinomyces species from cannabis users induce anxiety-like behavior in mice through mitochondrial dysfunction and reduced GABAergic signaling.

This study identifies genetic loci associated with opioid use disorder-related behaviors in rats using a genome-wide association approach and network-based clustering.

This study uses a non-linear clustering approach in rats to identify distinct behavioral and neuronal profiles associated with heroin vulnerability and resiliency, reflecting human opioid use disorder heterogeneity.

The paper shows that cocaine-trained mice have stable D1-MSNs in the NAcore that predict cue-induced cocaine seeking, unlike sucrose.

This study identifies a novel glutamatergic pathway from the medial prefrontal prelimbic cortex to the dorsal hippocampus CA1 that regulates methamphetamine-induced reward effects.

This study shows that long-access heroin self-administration in rats reduces grey matter volume in specific brain regions and alters microglia morphology, suggesting a link between neuroinflammation and structural brain changes.

The paper investigates MMP-2 and -9 activity in the nucleus accumbens core during methamphetamine cue-induced relapse in rats, finding increased MMP activity despite stable cue-induced seeking behavior over time.

This study identifies D2-MSN hyperactivity as a driver of antipsychotic-induced behavioral supersensitivity and its associated symptoms.

This paper describes a new experimental assay allowing mice to self-administer drugs while head-restrained, enabling simultaneous multiphoton imaging of neural activity during drug use and relapse.

This study investigates how CRMP2 and CaV2.2 interactions in the prefrontal cortex influence cocaine-seeking behavior and relapse.

This study identifies a subpopulation of prelimbic cortex neurons that become hyperexcitable after chronic cocaine exposure, and shows that restoring Kv7 channel function reduces cue-induced cocaine seeking.