Perikles D. Simon

This study evaluates a bead-based flow cytometry platform for detecting CNS-derived extracellular vesicles and identifying disease-specific markers in clinical samples.

This paper demonstrates that neutrophil extracellular traps (NETs) are a major source of mono-N cirDNA independent of apoptosis, and shows that NE and MPO contribute to NET autocatabolism and cirDNA release.

This study identifies granulocytes as the primary source of exercise-induced cfDNA, which can affect liquid biopsy accuracy in healthy individuals and patients with hematological malignancies.

The paper validates quantitative PCR assays for cfDNA detection without DNA extraction in SLE patients, showing reliable quantification and exercise-induced cfDNA kinetics.

The paper investigates DNA association with extracellular vesicles (EVs) in plasma during exercise, finding that DNA is primarily on the EV surface, not inside.