This study identifies a novel monomeric Aβ-activated signaling pathway in microglia that regulates brain development by inhibiting microglial immune activation and preventing neuronal ectopia.

eLife · Dec 5, 2024Peer-reviewedNeuroscience

Monomeric amyloid-β inhibits microglial inflammatory activity in the brain via an APP/heterotrimeric G protein-mediated pathway

Hyo Jun Kwon, Devi Santhosh, Zhen Huang

This study identifies an APP/heterotrimeric G protein-mediated pathway that suppresses microglial inflammation via Aβ monomers, revealing a novel regulatory mechanism in brain development and Alzheimer's disease.

bioRxiv · Jul 24, 2023 · PreprintNeuroscience

Establishing And Maintaining The Blood-Brain Barrier: Epigenetic And Signaling Determinants.

Jayanarayanan Sadanandan, Sithara Thomas, Iny Elizabeth Mathew, Zhen Huang, Spiros Blackburn, Nitin Tandon, Hrishikesh A. Lokhande, Pierre D. McCrea, Emery H. Bresnick, Pramod K. Dash, Devin William McBride, Arif O. Harmanci, Lalit Kishore Ahirwar, Dania Alphonse Jose, Ari Dienel, , Peeyush Kumar Thankamani Pandit

The paper identifies epigenetic and signaling factors that regulate BBB formation and maintenance in CNS endothelial cells.

bioRxiv · Nov 29, 2022Neuroscience