Author

Zhen Huang

National University of Defense Technology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Biology Disciplines

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Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:large language model· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Chiachin Wilson Lee· 1 shared David R. Healy· 1 shared Dongsheng LiiD· 1 shared Erik C. Ralph· 1 shared Feng Wang· 1 shared Heather Wheeler· 1 shared Hongguang ReniD· 1 shared Huixian WuiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMolecular Biology

Chiachin Wilson Lee

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2 papers

Recent·Most cited

SemVac: A Semantic Vaccinology Paradigm Powered by LLMs for Antigen Discovery

Yunxiang Zhao, You Shu, Linfeng Shu, Peng Lv, Xiangyang Chi, Dongsheng Li, J Q Zhang, Zhen Huang, Hongguang Ren, Junjie Xu, Xiaodong Zai, Wei Chen

SemVac uses LLMs to predict vaccine antigens by analyzing literature-derived protein descriptions, outperforming existing methods and identifying new candidates with experimental validation.

bioRxiv · Sep 15, 2026 · PreprintImmunology

Insight into the scaffolding function of USP18 from a high resolution cryo-EM structure of STAT2-USP18-ISG15 ternary complex

Kevin W. Huynh, Rachel Plumb, David R. Healy, Veronica Jové, Erik C. Ralph, Chiachin Wilson Lee, Heather Wheeler, Kymberly K. Levine, Zhen Huang, Kimberly F. Fennell, Richard A. Corpina, Timothy K. Craig, Paul D. Wes, Paula M. Loria, Monica Schenone, , Masaya Yamaguchi

The paper determines the structure of the STAT2-USP18-ISG15 ternary complex using cryo-EM, revealing how USP18's scaffolding function suppresses IFN-I signaling by disrupting its enzymatic activity.

bioRxiv · Feb 12, 2026 · PreprintMolecular Biology