Stéphanie Philtjens

The paper investigates how genetic background affects tau aggregate seeding in mice by analyzing RNA-seq and tau seeding activity data from four strains.

The paper identifies genetic variants affecting plasma protein levels in mice using pQTL mapping and describes a pipeline for drug target discovery.

The paper uses DREADD-activated astrocytes and single-cell RNA sequencing to show transcriptomic changes in astrocytes and microglia, highlighting gene pathways involved in neurogenesis and immune responses.