Cristian A. Lasagna‐Reeves

This study shows that TREM2 deficiency causes region-specific changes in vascular amyloid and tau pathology in a mouse model of cerebral amyloid angiopathy.

This study uses single-nucleus RNA sequencing to show that tau ablation alters brain cell programs in health and restores function in vascular amyloid disease.

The paper investigates the correlation between phosphorylation at serine 214 and tau seeding activity in mouse models, showing its role in tau propagation.

The paper identifies distinct protein interactors of Tau-seed in AD across species and brain regions, highlighting functional differences in Tau propagation.

This study shows that reducing Hexokinase 2 (HK2) in microglia slows Alzheimer's disease progression, but complete loss worsens inflammation, suggesting a complex role for HK2 in neuroinflammation.

The paper investigates how genetic background affects tau aggregate seeding in mice by analyzing RNA-seq and tau seeding activity data from four strains.

This study examines postmortem brains of AsymAD cases to identify mechanisms of cognitive resilience, finding enhanced microglial dynamics and reduced tau seeding in the amyloid plaque microenvironment.