Author

Yanwen You

Indiana University IndianapolisORCID 0000-0002-5168-9720Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Research Focus:cell-cell communication· 4 Research Focus:differential expression· 4 Approach:statistical model· 4 Research Focus:gene regulatory network inference· 3 Organism:mouse· 3 Organism:Drosophila· 2 Organism:human· 2 Assay:proteomics· 2

Frequent Co-Authors

Cristian A. Lasagna‐ReevesiD· 4 shared Pablo MartíneziD· 4 shared Nur JuryiD· 3 shared Hande KarahaniD· 2 shared Henika PateliD· 2 shared Javier Redding‐OchoaiD· 2 shared Juan Carlos TroncosoiD· 2 shared Jungsu KimiD· 2 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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4 shared papersNeuroscience

Cristian A. Lasagna‐ReevesORCID

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4 papers

Recent·Most cited

NeuroscienceJournal of Alzheimer s DiseasePeer-reviewedSep 1, 2025

Phosphorylation at serine 214 correlates with tau seeding activity in an age-dependent manner in two mouse models for tauopathies and is required for tau transsynaptic propagation.

Pablo Martínez, Nur Jury, Henika Patel…·Cristian A. Lasagna‐Reeves

The paper investigates the correlation between phosphorylation at serine 214 and tau seeding activity in mouse models, showing its role in tau propagation.

3 citations

mouseDrosophila

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NeurosciencebioRxivPreprintJun 17, 2025

Tau-seed interactome analysis reveals distinct functional signatures in Alzheimer's disease across model systems.

Pablo Martínez, Henika Patel, Yanwen You…·Cristian A. Lasagna‐Reeves

The paper identifies distinct protein interactors of Tau-seed in AD across species and brain regions, highlighting functional differences in Tau propagation.

1 citation

humanmouse

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NeuroscienceThe Journal of Experimental MedicinePeer-reviewedJul 28, 2023

Network analysis reveals strain-dependent response to misfolded tau aggregates

Dominic J. Acri, Yanwen You, Mason Douglas Tate…·Jungsu Kim

The paper investigates how genetic background affects tau aggregate seeding in mice by analyzing RNA-seq and tau seeding activity data from four strains.

3 citations

mousebulk RNA-seq

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NeurosciencebioRxivPreprintJul 27, 2023

Enhanced microglial dynamics and paucity of tau seeding in the amyloid plaque microenvironment contributes to cognitive resilience in Alzheimer 's disease

Nur Jury, Yanwen You, Pablo Martínez…·Cristian A. Lasagna‐Reeves

This study examines postmortem brains of AsymAD cases to identify mechanisms of cognitive resilience, finding enhanced microglial dynamics and reduced tau seeding in the amyloid plaque microenvironment.

3 citations

humanspatial transcriptomics

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