Jungsu Kim

Information processing-like phenotype of human brain organoids

This study quantifies information-processing-like properties of human cortical organoids using a functional phenotyping framework, linking network function to disease-related mutations and pharmacological perturbations.

Semi-automated annotation refinement accelerates cell type identification in brain spatial and single-cell studies

SAHA provides a statistical framework for rapid cell type annotation by transferring labels from reference datasets to query datasets without integration.

Single-nucleus transcriptomics reveal disrupted pathways in the prefrontal cortex of Scn2a-deficient mice

This study uses snRNA-seq to analyze gene expression changes in Scn2a-deficient mice, identifying disrupted pathways in neuronal subtypes of the prefrontal cortex.

EXOSC3 G191 Variants Trigger System-Wide Recalibration of RNA Processing Machinery

The paper investigates how EXOSC3 p.G191 variants affect RNA processing by analyzing transcriptomic, proteomic, and structural data in human cell models.

Tau Ablation Rewires Brain Cell Programs in Health and Restores Function in Disease

This study uses single-nucleus RNA sequencing to show that tau ablation alters brain cell programs in health and restores function in vascular amyloid disease.

Comparative analysis of nuclei isolation methods for brain single-nucleus RNA sequencing

This study compares three nuclei isolation methods for brain snRNA-seq, finding protocol-dependent differences in cell type proportions, transcriptional homogeneity, and RNA contamination levels.

Understanding monocyte-driven neuroinflammation in Alzheimers disease using human brain organoid microphysiological systems

This study uses human brain organoid microphysiological systems to show that AD patient monocytes cause increased inflammation and reduced Aβ clearance in organoids compared to controls.

Endogenous recapitulation of Alzheimers disease neuropathology through human 3D direct neuronal reprogramming

This study uses 3D direct neuronal reprogramming of AD patient fibroblasts to recapitulate AD neuropathology, showing A{beta} deposition, tauopathy, and neuronal death, and identifies potential therapeutic targets.

Robust single nucleus RNA sequencing reveals depot-specific cell population dynamics in adipose tissue remodeling during obesity

This study develops a robust snRNA-seq method to analyze depot-specific adipose tissue remodeling during obesity, identifying distinct adipocyte subpopulations and their functional trajectories.

miRNA family miR-29 inhibits PINK1-PRKN dependent mitophagy via ATG9A

The paper identifies miR-29 and ATG9A as regulators of mitophagy and discovers EOPD-linked variants in ATG9A.

Network analysis reveals strain-dependent response to misfolded tau aggregates

The paper investigates how genetic background affects tau aggregate seeding in mice by analyzing RNA-seq and tau seeding activity data from four strains.

Enhanced microglial dynamics and paucity of tau seeding in the amyloid plaque microenvironment contributes to cognitive resilience in Alzheimer 's disease

This study examines postmortem brains of AsymAD cases to identify mechanisms of cognitive resilience, finding enhanced microglial dynamics and reduced tau seeding in the amyloid plaque microenvironment.

Identification of genetic variants regulating the abundance of clinically relevant plasma proteins using the Diversity Outbred mouse model

The paper identifies genetic variants affecting plasma protein levels in mice using pQTL mapping and describes a pipeline for drug target discovery.

Disrupted structural connectivity in ArcAβ mouse model of Aβ amyloidosis

The paper examines structural connectivity and network topology in ArcAβ mice, finding disrupted connectivity and reduced network efficiency linked to Aβ amyloidosis.

Single-cell resolution analysis of the crosstalk between chemogenically activated astrocytes and microglia

The paper uses DREADD-activated astrocytes and single-cell RNA sequencing to show transcriptomic changes in astrocytes and microglia, highlighting gene pathways involved in neurogenesis and immune responses.