Author

Sandra Paulina Smieszek

Case Western Reserve UniversityORCID 0000-0002-8006-0454Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:GWAS / association mapping· 2 Organism:human· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Adam Christian NajiD· 1 shared Bartlomiej P. Przychodzen· 1 shared Christos M. Polymeropoulos· 1 shared Ellen L. PalmeriD· 1 shared Holly N. CukieriD· 1 shared Jonathan L. HainesiD· 1 shared Lars Anders ForsbergiD· 1 shared Margaret Ann Pericak‐VanceiD· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperGenetics

Adam Christian NajORCID

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2 papers

Recent·Most cited

GeneticsbioRxivPreprintNov 14, 2022

Somatic Loss of the Y Chromosome and Alzheimer's Disease Risk

Ellen L. Palmer, Penelope H. Benchek, Nicholas R. Wheeler…·William S. Bush

This study validates the association between mosaic loss of the Y chromosome and Alzheimer's Disease using prospective analyses and Mendelian Randomization across multiple cohorts.

4 citations

humanwhole-genome sequencing

𝕏 PostBluesky

Genetic & Genomic MedicinemedRxivPreprintJan 22, 2021

Role of FYVE and Coiled-Coil Domain Autophagy Adaptor 1 in severity of COVID-19 infection: from GWAS hit to therapeutic hypothesis

Sandra Paulina Smieszek, Bartlomiej P. Przychodzen, Christos M. Polymeropoulos…·Mihael H. Polymeropoulos

The paper identifies a genetic locus associated with severe COVID-19 and hypothesizes that downregulating FYCO1 with indomethacin may reduce viral replication and infectivity.

3 citations

humanwhole-genome sequencing

𝕏 PostBluesky