A role for Toll-like receptor 3 in lung vascular remodeling associated with SARS-CoV-2 infection
Daniela Farkas, Srimathi Bogamuwa, Bryce Piper, Geoffrey Newcomb, Pranav Gunturu, Joseph S. Bednash, James David Londino, Ajit Elhance, Richard Seonghun Nho, Oscar Rosas Mejia, Jacob S. Yount, Jeffrey Craig Horowitz, Elena A. Goncharova, Rama K. Mallampalli, Richard Robinson, László Farkas
This study identifies endothelial TLR3 insufficiency as a mechanism underlying SARS-CoV-2-induced lung vascular remodeling and suggests TLR3 agonists as a potential therapeutic strategy.
bioRxiv · Jan 25, 2023 · PreprintMolecular Biology