Jacob S. Yount

This study shows that reduced mitochondrial fitness in CD8 T cells, caused by TFAM insufficiency, leads to increased immunopathology during viral pneumonia and impaired protective immunity.

This study shows that Caspase-11 worsens severe SARS-CoV-2 by increasing inflammation and reducing CD8 T-cell immunity, but its removal improves viral clearance and survival.

This study characterizes the antiviral activities and regulatory mechanisms of diverse IFITM proteins in macaques, showing how gene duplication and retrotransposition generate functional diversity in antiviral defenses.

This study shows that gasdermin E is not essential for H1N1 influenza virus pathogenesis in mice, as Gsdme-/- mice exhibit similar infection outcomes to wild-type mice.

This study identifies Aiolos as a negative regulator of antigen-inexperienced, virtual memory CD8+ T cells, showing increased TVM cell numbers and function in its absence.

This study shows that activating AMPK in mice infected with a modified H1N1 virus reduces cardiac damage by restoring mitochondrial function and improving survival.

This study shows that IFITM3 knockout mice are a viable preclinical model for testing influenza vaccines due to their enhanced viral replication and functional immune responses.

This study uses an automated behavioral system and transcriptomic analysis to identify cognitive impairments in mice with long COVID, finding similar transcriptomic changes to humans.

This study shows that IFITM3 deficiency accelerates SARS-CoV-2 adaptation in mice, revealing how variant traits influence tropism and pathogenesis across hosts.

The paper identifies ERK5 as a potentiator of STAT1 activation and ISG expression, enhancing type III IFN-mediated antiviral responses in epithelial cells.

This study identifies endothelial TLR3 insufficiency as a mechanism underlying SARS-CoV-2-induced lung vascular remodeling and suggests TLR3 agonists as a potential therapeutic strategy.