David A. Brow

Direct RNA-seq provides evidence for an antiterminator function of the yeast Hrp1 protein on RNA polymerase II transcripts

The paper uses direct RNA sequencing to show Hrp1 affects RNA polymerase II termination and polyA site selection in yeast.

Substitutions in RNA-binding protein Hrp1 map a potential interaction surface with the yeast RNA polymerase II elongation complex

The paper identifies Hrp1 as an RNAP II anti-termination factor and shows specific substitutions in Hrp1 and Rpb3 affect termination by altering protein interactions.

Yeast U6 snRNA made by RNA polymerase II is less stable but functional

The paper shows that U6 snRNA made by RNA polymerase II is less stable but still functional in yeast, and that Sm protein binding can enhance its stability.