Samuele Negro

This study presents a spatiotemporal multi-omics analysis of aging neuromuscular junctions in mice, identifying genes with decoupled transcript and protein trajectories and highlighting post-transcriptional regulation in NMJ aging.

This study shows that disrupting peroxisomal-mitochondrial interactions in skeletal muscle accelerates muscle dysfunction and age-related degeneration.

This study shows that targeting NMJ regeneration and CXCR4 can improve motor function and survival in ALS models.

The paper investigates axonal transport dynamics of signalling endosomes and mitochondria at the Node of Ranvier in vivo, finding reduced velocity and increased pausing during transit through the NoR.