Fabio Lauria

This study presents a spatiotemporal multi-omics analysis of aging neuromuscular junctions in mice, identifying genes with decoupled transcript and protein trajectories and highlighting post-transcriptional regulation in NMJ aging.

RiboWich improves ribosome profiling by eliminating ribosome purification and enabling high-throughput, low-input translatome analysis.

The paper introduces Cell Marker Accordion, a tool for accurate and interpretable single-cell and spatial omics annotation across health and disease contexts.

The paper identifies COL1A1 as a translation-specific biomarker of SMA severity and shows it can be rescued by SMN-restoring therapies in multiple models.

This study investigates how TDP-43 dysregulation disrupts protein synthesis in ALS models by altering ribosome dynamics and mRNA homeostasis, revealing a conserved mechanism across in vitro and in vivo systems.

This study characterizes two TDP-43 proteinopathy models in mouse neurons, revealing reduced axonal translation, increased oxidative stress, and presynaptic dysfunction linked to mRNA metabolism disruption.

The paper introduces expressyouRcell, an R package that visualizes gene expression and protein level changes across time and space using dynamic cellular pictographs.

The paper introduces circAID-p-seq, a PCR-free method for phospho-RNA sequencing, and demonstrates its application in ribosome profiling to study RNA-protein interactions.

The paper shows SMN protein binds ribosomes and modulates translation of specific mRNAs in SMA, causing translational defects in motor neuron-related proteins.

riboWaltz optimizes P-site positioning in ribosome profiling data, improving accuracy and visualization of ribosome locations compared to existing tools.

The paper introduces RiboLace, a method to isolate active ribosomes for ribosome profiling, enabling high-resolution analysis of active translation.