The CD112-TIGIT/PVRIG Axis Mediates NK Cell Evasion inDecitabine-Treated Acute Myeloid Leukemia Cells
Keisuke Nakamura, Ikuko Omori, Naru Sato, Susumu Goyama, Toshio Kitamura, Yutaka Enomoto
This study shows that decitabine treatment increases CD112 expression in AML cells, which reduces NK cell-mediated cytotoxicity through the CD112-TIGIT/PVRIG axis, suggesting a strategy to enhance antileukemic activity by blocking this axis.
bioRxiv · Sep 10, 2026 · PreprintCancer Biology