Cancer BiologybioRxivPreprint
The CD112-TIGIT/PVRIG Axis Mediates NK Cell Evasion inDecitabine-Treated Acute Myeloid Leukemia Cells
Keisuke Nakamura, Ikuko Omori, Naru Sato…·Yutaka Enomoto
This study shows that decitabine treatment increases CD112 expression in AML cells, which reduces NK cell-mediated cytotoxicity through the CD112-TIGIT/PVRIG axis, suggesting a strategy to enhance antileukemic activity by blocking this axis.
DOI 10.64898/2026.09.07.749773