Susumu Goyama

Development of CRISPR/Cas13-based analytical tools to study RNA-Protein Interactions

The paper develops CRISPR/Cas13-based tools to analyze RNA-protein interactions by integrating existing PPI methods with RNA-targeting Cas13, demonstrating their utility in studying paraspeckles.

The CD112-TIGIT/PVRIG Axis Mediates NK Cell Evasion inDecitabine-Treated Acute Myeloid Leukemia Cells

This study shows that decitabine treatment increases CD112 expression in AML cells, which reduces NK cell-mediated cytotoxicity through the CD112-TIGIT/PVRIG axis, suggesting a strategy to enhance antileukemic activity by blocking this axis.

Midbody inheritance predicts re-entry into quiescence, but not lineage potential, in mouse hematopoietic stem cells

This study shows midbody inheritance in HSCs delays re-entry into the next cell cycle but does not affect lineage potential.

DNA barcoding-based paired daughter cell analysis reveals division preferences of hematopoietic stem cells

The paper develops a DNA barcoding-based method to analyze HSC daughter cell pairs, revealing biased division patterns toward symmetric divisions and linking these to molecular features.

Pathway-Centric Integration of CRISPR Fitness with Molecular Features Draws Cancer State Maps

StateMap integrates CRISPR fitness and gene expression data to map cancer pathway states, identifying therapeutic vulnerabilities in the Hippo pathway.

MECOM promotes leukemia progression and inhibits mast cell differentiation through functional competition with GATA2

This study shows that MECOM mutations impair DNA binding and functionally antagonize GATA2, promoting leukemia and inhibiting mast cell differentiation.

Cohesin constrains histone modification-driven chromatin dynamics

This study shows that mutations in Asxl1 and Stag2 cause dysregulation of histone modifications and chromatin structures, leading to aberrant gene upregulation and myelodysplastic syndromes.

Plcl1 Regulates Hematopoietic Stem Cell Function During Aging and Stress by Modulating Calcium Dynamics

This study identifies Plcl1 as a regulator of calcium dynamics in hematopoietic stem cells, affecting their function during aging and stress.

Hematopoietic stem cells undergo bidirectional fate transitions in vivo

This study reveals bidirectional fate transitions between myeloid-biased and lineage-balanced hematopoietic stem cells using clonal phylogenetic tracing.

CH-related Mutant ASXL1 Promotes Atherosclerosis in Mice via Dysregulated Innate Immunity

This study shows that ASXL1 mutations in mice promote atherosclerosis by dysregulating innate immunity through impaired inhibition of NF-κB signaling.

Latent mitotic vulnerability of AML cells induced by therapeutic agents

This study identifies mitotic vulnerabilities in AML cells induced by therapeutic agents, showing increased cytotoxicity during mitosis compared to S/G2 phase arrest.

PRDM proteins control Wnt/β-catenin activity to regulate craniofacial chondrocyte differentiation

This study shows that Prdm3 and Prdm16 regulate Wnt/β-catenin activity to control craniofacial chondrocyte differentiation and development.

The conserved and divergent roles of Prdm3 and Prdm16 in zebrafish and mouse craniofacial development

This study examines the roles of Prdm3 and Prdm16 in craniofacial development across zebrafish and mice, revealing conserved and divergent functions in gene regulation and epigenetic modifications.