Synthetic BiologybioRxivPreprint
Essential function of femaleless in female gametogenesis controls gene drive spread in Anopheles gambiae
Barbara Fasulo, William T. Garrood, James Philpott…·Andrea Crisanti
This study investigates the role of the femaleless gene in Anopheles gambiae gametogenesis and its impact on CRISPR-Cas9 gene drive efficacy, showing that disrupting fle causes female sterility and limits gene drive spread.
DOI 10.64898/2026.08.22.746406