Author

Rui Zhu

Yale UniversityORCID 0000-0002-8059-6718Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Rui Zhu1 paper · Sichuan University

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:variant effect prediction· 2 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Hang ZhouiD· 2 shared Lucila Ohno-machado AiD· 2 shared Adebowale AdeniraniD· 1 shared Alzheimer’s Disease Neuroimaging Initiative· 1 shared Arpita Neogi· 1 shared Arya ManiiD· 1 shared Brisa Paliuqi· 1 shared Dipanjan BanerjeeiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersGenetics

Hang ZhouORCID

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2 papers

Recent·Most cited

Variant-Specific Rewiring of Lysosomal Positioning by STARD9 Produces Opposite Cholesterol Trafficking Outcomes

Mehdi Dianatpour, Dipanjan Banerjee, HyunKyung Kim, Jiyoung Moon, Rui Zhu, Hang Zhou, Arpita Neogi, Trojan Rugira, Shrikant Mane, Adebowale Adeniran, Brisa Paliuqi, Ho‐Joon Lee, Lucila Ohno-machado A, Arya Mani

The paper identifies STARD9 as a causal gene for dyslipidemias and atherosclerosis, showing how its variants alter lysosomal positioning and cholesterol trafficking with opposing effects on HDL and triglycerides.

bioRxiv · Sep 26, 2026 · PreprintGenetics

Advancing Human Population Genomics with DNA Foundation Models

Rui Zhu, Xiaopu Zhou, Marla Mendes de Aquino, Worrawat Engchuan, Hang Zhou, Haoyu Cheng, Alzheimer’s Disease Neuroimaging Initiative, John Hardy, Haixu Tang, Stephen W. Scherer, Lucila Ohno-machado A

This study introduces a DNA foundation model to assess functional genetic variation across diverse populations, demonstrating its utility in understanding Alzheimer's disease risk and ancestry-specific gene expression.

medRxiv · Sep 9, 2025 · PreprintGenetic & Genomic Medicine