Variant-Specific Rewiring of Lysosomal Positioning by STARD9 Produces Opposite Cholesterol Trafficking Outcomes
Mehdi Dianatpour, Dipanjan Banerjee, HyunKyung Kim, Jiyoung Moon, Rui Zhu, Hang Zhou, Arpita Neogi, Trojan Rugira, Shrikant Mane, Adebowale Adeniran, Brisa Paliuqi, Ho‐Joon Lee, Lucila Ohno-machado A, Arya Mani
The paper identifies STARD9 as a causal gene for dyslipidemias and atherosclerosis, showing how its variants alter lysosomal positioning and cholesterol trafficking with opposing effects on HDL and triglycerides.
bioRxiv · Sep 26, 2026 · PreprintGenetics