Arya Mani

The paper identifies STARD9 as a causal gene for dyslipidemias and atherosclerosis, showing how its variants alter lysosomal positioning and cholesterol trafficking with opposing effects on HDL and triglycerides.

This study shows that deleting KLF4 in maternal endothelium causes gestational hypertension and features of preeclampsia, offering a new mouse model for studying the disease.

This study identifies PAD-associated SNPs with stronger associations with surgical intervention than premature onset using UK Biobank data.

This study identifies latrophilin-2 as an upstream mechanosensor for fluid shear stress in endothelial cells, linking it to vascular development and disease.

This study identifies Dyrk1b as a key kinase integrating Fgf, Shh, and mTORC1 signaling in skeletal muscle development and homeostasis through zebrafish and C2C12 cell models.

This study shows TCF7L2 promotes VSMC differentiation and inhibits proliferation, reducing intimal hyperplasia in mice with LRP6 mutations.