Affinity-enhanced peptides delivered by mRNA-LNPs inhibit influenza A virus replication by disrupting the PA-PB1 interaction
Alberto Florez Prada, Chloé Sturmach, Nabila Laroui, Nicolas Pautrieux, Camile Bourgneuf, Philippe J. Mas, Rémy Lartia, Didier Boturyn, Wim Pascal Burmeister, Chantal Pichon, Nadia Naffakh, Catherine Isel, Darren J. Hart
The paper identifies and delivers peptides that disrupt the PA-PB1 interaction in influenza polymerase, inhibiting viral replication in cultured cells.
bioRxiv · Jul 31, 2026 · PreprintMicrobiology