Nadia Naffakh

The paper identifies and delivers peptides that disrupt the PA-PB1 interaction in influenza polymerase, inhibiting viral replication in cultured cells.

DIPScan detects and corrects defective viral genomes in sequencing data to improve consensus genome accuracy for influenza virus.

This study reveals the molecular mechanisms of cap-snatching by influenza polymerase using cryo-EM structures of FluPol bound to Pol II and DSIF.

This study shows human MX1 restricts influenza A virus by sequestering vRNPs in cytoplasmic clusters via dynein and microtubules, reducing viral production.

This study identifies ATG16L1's role in IAV-induced PI4P production at the ER, facilitating vRNP egress by coordinating RAB11A and PI4P-enriched membranes.

The paper reveals ANP32's role as an electrostatic chaperone stabilizing influenza polymerase complexes, explaining host adaptation and providing structural insights into replication complexes.

The paper presents a high-resolution structure of influenza polymerase showing the role of a conserved dibasic motif in replication initiation.

The paper investigates monocyte subset heterogeneity and its impact on influenza virus susceptibility across populations, revealing differences in transcriptional responses and infection resistance between African and European ancestry individuals.