Mariano Labrador

Distinct principles of genome compartmentalization in Drosophila and humans revealed by osmotic stress

This study compares genome compartmentalization in Drosophila and humans under osmotic stress, revealing distinct organizational principles involving LLPS and architectural proteins.

Interactions Between the Histone Variant H2Av and the Suppressor of Hairy wing Insulator Influence the DNA Damage Response and Lymph Gland Development in Drosophila

This study shows that Su(Hw) insulator proteins and H2Av histone variant interact to regulate DNA damage response and lymph gland development in Drosophila.

Drosophila insulator proteins exhibit in-vivo liquid-liquid phase separation properties

This study identifies liquid-liquid phase separation properties in Drosophila insulator proteins and shows their role in forming nuclear foci during stress and apoptosis.

A Phosphorylated Histone H2A Variant Displays Properties of Chromatin Insulator Proteins in Drosophila

This study shows that phosphorylated histone H2Av interacts with chromatin insulator proteins and is involved in genome stability through its association with TAD boundaries and insulator bodies.

Mutations in the Insulator Protein Suppressor of Hairy Wing Induce Genome Instability

This study investigates the role of the Drosophila insulator protein Su(Hw) in genome stability, finding that its mutation leads to oogenesis defects and DNA damage.

A Drosophila Insulator Interacting Protein Suppresses Enhancer-Blocking Function and Modulates Replication Timing

This study investigates the role of HIPP1, a partner of the Drosophila Su(Hw) insulator protein, showing it suppresses enhancer-blocking function and affects DNA replication timing.