This study compares genome compartmentalization in Drosophila and humans under osmotic stress, revealing distinct organizational principles involving LLPS and architectural proteins.

bioRxiv · Apr 6, 2026 · PreprintGenomics

Transcriptional profiling of Hutchinson-Gilford Progeria syndrome fibroblasts reveals deficits in mesenchymal stem cell commitment to differentiation related to early events in endochondral ossification.

Rebeca San Martin, Priyojit Das, Jacob T. Sanders, Ashtyn M Hill, Rachel Patton McCord

This study identifies transcriptional deficits in HGPS fibroblasts related to mesenchymal differentiation and endochondral ossification, with age-dependent gene expression changes.

eLife · Dec 29, 2022Peer-reviewedGenomics

Loops, TADs, Compartments, and Territories are Elastic and Robust to Dramatic Nuclear Volume Swelling

Jacob T. Sanders, Rosela Golloshi, Peyton H. Terry, Darrian G. Nash, Yang Xu, Job Dekker, Rachel Patton McCord

The paper investigates how genome structure responds to nuclear swelling, finding that global topology remains elastic and robust despite dramatic volume changes.

bioRxiv · Aug 20, 2021 · PreprintGenomics

Radiation-Induced DNA Damage and Repair Effects on 3D Genome Organization

Jacob T. Sanders, Trevor F. Freeman, Yang Xu, Rosela Golloshi, Mary A. Stallard, Ashtyn M Hill, Rebeca San Martin, Adayabalam S. Balajee, Rachel Patton McCord

This study examines how DNA damage and repair affect 3D genome organization using Hi-C in different cell types, finding cell-type-specific changes and TAD boundary strengthening in repair-proficient cells.

Nature Communications · Dec 2, 2020Peer-reviewedGenomics

Iteratively Improving Hi-C Experiments One Step at a Time

Rosela Golloshi, Jacob T. Sanders, Rachel Patton McCord

This paper evaluates Hi-C protocol modifications and identifies factors affecting data quality and DNA loss in Hi-C experiments.

Methods · Apr 30, 2018Peer-reviewedGenomics