James Ryan Simmons

The paper identifies a sequence motif, SFE, that is necessary and sufficient for generating DNA double-strand breaks and telomere healing during programmed DNA elimination in nematodes.

The paper investigates spatial genome organization during programmed DNA elimination in nematodes, showing conserved 3D genome reorganization across species.

The paper investigates programmed DNA elimination (PDE) in parasitic nematodes, showing how it leads to karyotype changes through chromosome fusion and DNA loss.

This study shows that Su(Hw) insulator proteins and H2Av histone variant interact to regulate DNA damage response and lymph gland development in Drosophila.

This paper establishes Oscheius tipulae as a genetic model for studying programmed DNA elimination (PDE) and identifies conserved motifs and mechanisms involved in DNA loss during embryogenesis.

This study shows that phosphorylated histone H2Av interacts with chromatin insulator proteins and is involved in genome stability through its association with TAD boundaries and insulator bodies.

This study investigates the role of the Drosophila insulator protein Su(Hw) in genome stability, finding that its mutation leads to oogenesis defects and DNA damage.

This study investigates the role of HIPP1, a partner of the Drosophila Su(Hw) insulator protein, showing it suppresses enhancer-blocking function and affects DNA replication timing.