Membrane Interfacial Potential Governs Surface Condensation and Fibrillation of α-Synuclein in Neurons
Jafarulla Shaikh, Aniruddha Nagarajan, Tuhina Mitra…·Mohammed Saleem
This study shows that lipid membrane interfaces drive α-synuclein condensation and fibrillation at low concentrations, revealing a mechanism for its propagation in neurodegeneration.