Sandeep Choubey

This study shows tau forms multilayered condensates on microtubules via a prewetting-like transition, creating a selective microenvironment that restricts some proteins while recruiting others.

The paper identifies a sensory pathway in Flavobacterium johnsoniae that controls the transition between swarming and zorbing, linking environmental sensing to collective behavior and spatial organization.

This study shows that mycobacterial load and direct contact determine phagosome fate by altering membrane mechanics, leading to spacious or compact phagosomal states that influence bacterial egress.

This study investigates how phase separation of transcription factors affects the dynamics of gene regulatory motifs, showing it tunes stability and noise in network behavior.

This study identifies Leiomodin 2 as a processive actin polymerase that elongates pointed ends of actin filaments, linking its dysfunction to dilated cardiomyopathy.

This study shows that lipid membrane interfaces drive α-synuclein condensation and fibrillation at low concentrations, revealing a mechanism for its propagation in neurodegeneration.

This paper introduces a moments-based framework to infer transcriptional kinetics from nascent RNA data, showing improved accuracy in model selection and distinguishing promoter activation mechanisms.

This paper develops a polymer-based model to study how DNA sequence affects protein-DNA co-condensation, showing that sequence heterogeneity leads to multiple condensates.

The paper develops a generalized kinetic model to understand how multiple actin-binding proteins regulate filament length dynamics in vivo.

This study reveals how ESAT-6 disrupts the phagosomal membrane through fibril-mediated vesiculation, leading to host cell death and promoting Mtb infection.

This study investigates how Lsr2 protein interacts with DNA in Mycobacterium tuberculosis to compact the genome, revealing sequence-dependent co-condensation as a mechanism for gene regulation.

This study uses a polymer-based model to show how protein-protein interactions and DNA sequence influence chromatin organization and compartmentalization.

This study investigates transcriptional logic out of equilibrium and finds that non-equilibrium binding of transcription factors enables new logic operations not accessible in equilibrium.

The paper develops a kinetic model to analyze temporal organelle abundance dynamics from time-lapse imaging data, revealing distinct noise behaviors that distinguish different biogenesis mechanisms.

The paper investigates regulatory asymmetry in a negatively regulated single-input module (SIM) network, finding that the TF gene experiences stronger repression than its targets despite identical regulatory DNA.