The paper develops PhosTF to infer kinase/phosphatase regulation of transcription factors in yeast, finding that over 70% of interactions involve deactivation.

bioRxiv · Sep 3, 2021 · PreprintSystems Biology

Comparing Phylogeographies: Incompatible Geographical Histories in Pathogens' Genomes

Benjamin J. Singer, Antonello Di Nardo, Jotun Hein, Luca Ferretti A

The paper develops new measures to compare geographic histories in pathogens' genomes, revealing diverse diffusion paths in viral evolution.

bioRxiv · Jan 10, 2020 · PreprintGenomics

Evolutionary analyses of base-pairing interactions in DNA and RNA secondary structures

Michael Golden, Ben Murrell, Darren Patrick Martin, Oliver G. Pybus, Jotun Hein

MESSI infers coevolution rates of base-pairing interactions in nucleic acid sequences and identifies functionally important substructures.

Molecular Biology and Evolution · Oct 29, 2019Peer-reviewedMolecular Biology

Genomic Rearrangements Considered as Quantitative Traits

Martha Imprialou, André Kahles, Joshua G. Steffen, Edward J. Osborne, Xiangchao Gan, Janne Lempe, Amarjit Bhomra, Eric J. Belfield, Anne M. Visscher, Robert Greenhalgh, Nicholas P. Harberd, Richard Goram, Jotun Hein, Alexandre Robert‐Seilaniantz, Jonathan D. G. Jones, , Richard Mott

The paper develops a method to map structural variants as quantitative traits in Arabidopsis, identifying transpositions and their phenotypic effects using low-coverage sequencing data.

Genetics · Feb 8, 2017Peer-reviewedGenetics