Richard Mott

This study examines the Central Dogma in Arabidopsis thaliana, showing that codon frequencies and mRNA levels are better predictors of protein expression than methylation, tRNA, or ribosome-associated transcripts.

This paper introduces a homomorphic encryption method for genotypes and phenotypes to enable secure collaborative genomic analyses while preserving data confidentiality.

The paper investigates dominance and additivity in mammalian genetics, finding dominance accounts for 25% of heritable variance and reveals novel dominance QTLs and trans-acting effects in gene expression.

The paper uses multi-trait genomic prediction models and simulations to show that complex trait genetic architecture improves long-term genetic gains in wheat breeding.

The paper develops and applies RALLY, a selection mapping approach, to identify loci under historical selection in winter wheat varieties bred from 1916 to 2010.

The paper identifies 554 consensus genes in outbred rats and humans associated with body weight and BMI, revealing shared genetic regulatory mechanisms relevant for obesity.

The paper combines data from two independent mouse studies to identify genetic loci for traits, finds poor replication rates, and proposes a method to assess confidence in associations.

The paper analyzes haplotype diversity and genetic associations in wheat breeding lines to understand polygenic trait architecture and breeding implications.

This paper introduces a homomorphic encryption method for genotypes and phenotypes to enable privacy-preserving quantitative genetic analysis across studies.

The paper identifies coping-style behaviors in rats with enhanced parent-of-origin heritability and confirms these effects through reciprocal crosses.

The paper reanalyzes exome-sequenced schizophrenia cases and controls, finding significant enrichment of gene sets related to synaptic function, particularly involving FYN and NMDA receptor subunits.

The paper presents full-length de novo genome assemblies for 16 inbred mouse strains, identifying strain-specific haplotypes and novel functional loci, including a large unannotated gene with potential developmental roles.

The paper shows that rRNA gene copy number variation in Arabidopsis thaliana is heritable but unstably inherited, explaining why GWAS failed to identify the NORs as the source.

The paper develops a method to map structural variants as quantitative traits in Arabidopsis, identifying transpositions and their phenotypic effects using low-coverage sequencing data.

This study identifies Rhbdf2 as a gene influencing bone microarchitecture through a genome-wide association study in Collaborative Cross mice.