Christopher Thomas Workman

This study demonstrates the use of microplate readers to analyze biosensor signals from microbial colonies, showing improved sensitivity and dynamic range for various fluorescent reporters.

The paper identifies a central state transition in yeast molecular networks linked to PKA and TOR signaling, showing how genetic variants can cause global or local molecular changes affecting multiple cellular traits.

The paper develops PhosTF to infer kinase/phosphatase regulation of transcription factors in yeast, finding that over 70% of interactions involve deactivation.

The paper evaluates three OD calibration protocols for bacterial cell count estimation and recommends serial dilution of silica microspheres for its precision and compatibility with flow cytometry.

The paper shows that cooperative activation of dimeric transcription factors can arise from independent ligand binding events and is stabilized by DNA binding.

This study provides a comprehensive TSS map for fission yeast under various stress and media conditions using CAGE, revealing new insights into gene regulation and promoter diversity.