Jonathan D. G. Jones

Recognition-dependent activation of the RRS1-R/RPS4 immune receptor complex

This study investigates the oligomerization and activation mechanism of the RPS4-RRS1 immune receptor complex in Arabidopsis, showing that effector recognition triggers conformational changes that enable NADase activity.

Diverse haplotypes at a complex Solanum americanum locus confer resistance to Phytophthora infestans and P. capsici

The paper identifies two resistance genes from Solanum americanum that confer resistance to Phytophthora pathogens and shows their NLR cluster evolves in response to multiple pathogens.

Broad-spectrum polerovirus resistance conferred by a potato TIR-NLR immune receptor

The paper identifies Rladg, a potato TIR-NLR receptor that confers broad-spectrum resistance to poleroviruses by recognizing conserved protease structures.

Canonical NLR immune receptor architecture enforces EDS1-dependency onto divergent TIR domains

The paper shows that NLR immune receptor architecture enforces EDS1-dependency on diverse TIR domains in plants.

Host specificity in cereal rust fungi is mediated by a conserved glycoside hydrolase family

The paper identifies a conserved glycoside hydrolase family in leaf rust fungi that interacts with barley LecRKs to mediate non-host resistance, showing functional conservation across cereal species.

A helper NLR channels organellar calcium to trigger plant immunity

This study identifies NRG1 as a plant NLR receptor that targets chloroplasts to trigger immunity by channeling stromal calcium into the cytosol, revealing a novel mechanism for organelle-specific immune signaling.

An activated wheat CCG10-NLR immune receptor forms an octameric resistosome

Activated wheat CCG10-NLR immune receptor WAI3 and Arabidopsis RPS2 assemble into octameric calcium-permeable resistosomes with an inverted coiled-coil domain topology associated with lacking the conserved EDVID motif.

Structural basis for the broad recognition specificity of an Arabidopsis immune receptor

This study determines the structural basis of broad recognition by the Arabidopsis NLR WRR4A, revealing a shape-based mechanism that enables recognition of diverse effectors with similar three-dimensional architectures.

Diploid potato lines for the study and improvement of starch metabolism and structure

This study characterizes tuber and starch properties in diploid potato lines and their hybrids, showing variation in starch structure and yield traits.

Structural basis for heat tolerance in plant NLR immune receptors.

The paper identifies structural features that confer heat tolerance in plant NLR immune receptors and enables in silico classification and engineering of temperature-tolerant variants.

Uncoupling hypersensitive cell death response and disease resistance activated by effector-triggered immunity

This study uncouples hypersensitive cell death from disease resistance in plants by showing that HR is not essential for effective immunity.

Cell-type-specific execution of effector-triggered immunity

The paper profiles ETI responses across Arabidopsis leaf cell types using single-cell transcriptomics and finds cell-type-specific immune module activation.

Interfamily co-transfer of sensor and helper NLRs extends immune receptor functionality between angiosperms

The paper demonstrates that co-transferring sensor and helper NLRs from Solanaceae to rice, soybean, and Arabidopsis can extend immune receptor functionality across plant families.

Defense-Suppressive Fragments of RIN4 generated by AvrRpt2 Participate in NDR1-dependent Activation of RPS2

The paper identifies non-membrane-tethered RIN4 fragments generated by AvrRpt2 that activate RPS2, requiring NDR1 and overcoming suppression by the membrane-tethered C-terminal fragment.

Berberine Bridge enzyme-like oxidases orchestrate homeostatic control and signaling of oligogalacturonides in defense and wounding

This study shows that OGOX enzymes regulate oligogalacturonide levels, affecting plant immunity and tissue repair by balancing active OGs and oxidized oxOGs.

Enhancing plant broad-spectrum resistance through engineered pattern recognition receptors

This study engineers pattern recognition receptors to enhance broad-spectrum resistance in plants, showing improved efficacy in tomato, rice, and poplar.

Reversible ubiquitination of integrated domain controls paired NLR immune receptor complex homeostasis

The paper identifies a ubiquitination-deubiquitination cycle regulating the stability and function of the paired NLR receptor complex RRS1/RPS4 in Arabidopsis.

Identification of Avramr1 from Phytophthora infestans using long read and cDNA pathogen-enrichment sequencing (PenSeq)

This study identifies the Avr gene Avramr1 from Phytophthora infestans using long-read and cDNA pathogen-enrichment sequencing, revealing key insights into effector evolution and polymorphism.

Resistance gene discovery and cloning by sequence capture and association genetics

This paper clones four stem rust resistance genes in wild diploid wheat using association genetics and R gene enrichment sequencing within six months.

Physical and transcriptional organisation of the bread wheat intracellular immune receptor repertoire

The paper develops NLR-Annotator to identify NLR genes in wheat genomes and characterizes their structure, phylogeny, and expression, finding 3,400 NLR loci with 88% low basal expression.

Genomic Rearrangements Considered as Quantitative Traits

The paper develops a method to map structural variants as quantitative traits in Arabidopsis, identifying transpositions and their phenotypic effects using low-coverage sequencing data.