Author

Andrea D. Lipińska

Gdańsk Medical UniversityORCID 0000-0002-8115-9499Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

Aleksandra HeciD· 1 shared Igor ZhukoviD· 1 shared Jan BarczyńskiiD· 1 shared Magdalena J. ŚlusarziD· 1 shared Małgorzata GrauliD· 1 shared Marcelino ArciniegaiD· 1 shared Michał MikitiukiD· 1 shared Michał RychłowskiiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperMolecular Biology

Aleksandra HecORCID

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2 papers

Recent·Most cited

Unlocking viral evasion: Luminal charge interactions in BoHV-1 UL49.5 allosterically control TAP degradation

Natalia Karska, Małgorzata Graul, Igor Zhukov, Sylwia Rodziewicz‐Motowidło, Andrea D. Lipińska, Magdalena J. Ślusarz

This study identifies N-terminal electrostatic interactions in BoHV-1 UL49.5 as allosteric determinants of TAP degradation, showing that TAP degradation can be uncoupled from MHC class I downregulation.

bioRxiv · Jun 12, 2026 · PreprintBiochemistry

IGF2 Peptide-Based LYTACs for Targeted Degradation of Extracellular and Transmembrane Proteins

Michał Mikitiuk, Jan Barczyński, Przemysław Bielski, Marcelino Arciniega, Urszula Tyrcha, Aleksandra Hec, Andrea D. Lipińska, Michał Rychłowski, Tad A. Holak, Tomasz Sitar

This paper develops IGF2-based LYTACs for lysosomal degradation of extracellular and transmembrane proteins, showing enhanced in vitro effects compared to anti-PD-L1 antibodies.

Molecules · Nov 10, 2023Peer-reviewedMolecular Biology