Subclonal mutation load predicts survival and response to immunotherapy in cancers with low to moderate tumor mutation burden
Yujie Jiang, Matthew D. Montierth, Kaixian Yu, Shuangxi Ji, Quang Tran, Xiaoqian Liu, Jessica C. Lal, Shuai Guo, Aaron Wu, Yaoyi Dai, Seung Jun Shin, Ruonan Li, Shaolong Cao, Yuxin Tang, Tom Lesluyes, , Wenyi Wang
The paper develops CliPP to estimate subclonal mutation load (sML) and shows it predicts survival and immunotherapy response in cancers with low to moderate TMB.
bioRxiv · Jul 3, 2024 · PreprintGenomics