Aaron Wu

Distinct sensing of BCAAs by mTOR and c-Myc governs T cell proliferation, independent of catabolism

This study shows that BCAAs are sensed differently by mTOR and c-Myc in T cells, governing proliferation independently of catabolism.

Environmental Amino Acid Sensing Regulates the Rate of ASC Translation and NLRP3 Inflammasome Assembly

This study shows that environmental branched-chain amino acids regulate ASC translation and NLRP3 inflammasome assembly through mTOR-dependent translational bursting.

Glucose availability tunes latent CD8+ T cell expansion potential through a mitogen-independent, mTOR-dependent regulatory switch

This study shows glucose availability independently regulates CD8+ T cell expansion potential through mTOR-dependent mechanisms, distinct from mitogenic signals.

Subclonal mutation load predicts survival and response to immunotherapy in cancers with low to moderate tumor mutation burden

The paper develops CliPP to estimate subclonal mutation load (sML) and shows it predicts survival and immunotherapy response in cancers with low to moderate TMB.

Scalable subclonal reconstruction of cancer cells in DNA sequencing data using a penalized likelihood model

CliPP reconstructs subclonal architecture in cancer DNA sequencing data efficiently and accurately, outperforming existing methods in speed while maintaining high concordance with consensus calls.