Targeted recruitment of USP15 enhances CTLA4 surface levels and restricts its degradation.
Francesca Querques, Victoria Ciampani, Pei Yee Tey, Victoria D. Kutilek, Elma Kadić, Michael J. Clague, Sylvie Urbé
This paper demonstrates that targeted recruitment of USP15 stabilizes CTLA4 at the cell surface by redirecting it from lysosomal degradation, providing a foundation for ENTAC design.
Life Science Alliance · Jan 9, 2026Peer-reviewedCell Biology