This study identifies TGFβ-induced SMAD1/5 activation as critical for transient EMT in trophoblasts, linking it to placental development and preeclampsia.

bioRxiv · Jul 21, 2025 · PreprintMolecular Biology

Genome-wide analyses identify 21 infertility loci and over 400 reproductive hormone loci across the allele frequency spectrum

Samvida S. Venkatesh, Laura B. L. Wittemans, Duncan S. Palmer, Nikolas A. Baya, Teresa Cruz Ferreira, Barney Hill, Frederik Heymann Lassen, Melody J Parker, Saskia Reibe, Ahmed Elhakeem, Karina Banasik, Mie Topholm Bruun, Christian Erikstrup, Bitten Aagaard, Anders Juul, , Cecilia M. Lindgren

This study identifies 21 infertility loci and over 400 reproductive hormone loci through GWAS across multiple cohorts, finding limited genetic correlation between reproductive hormones and infertility.

Nature Genetics · Apr 14, 2025Peer-reviewedGenetic & Genomic Medicine

Genetic effects on the timing of parturition and links to fetal birth weight

Pol Solé-Navais, Christopher J. Flatley, Valgerður Steinthórsdóttir, Marc Vaudel, Julius Juodakis, Jing Chen, Triin Laisk, Abigail Leavitt LaBella, David Westergaard, Jonas Bačelis, Ben Michael Brumpton, Line Skotte, Maria Carolina Borges, Øyvind Helgeland, Anubha Mahajan, , Bo Jacobsson

This study identifies genetic loci associated with gestational duration and preterm delivery, showing maternal and fetal genetic effects and antagonistic pleiotropy with birth weight.

Nature Genetics · Apr 1, 2023Peer-reviewedGenetic & Genomic Medicine