Debbie A. Lawlor

Multi-ancestry, trans-generational GWAS meta-analysis of gestational diabetes and glycaemic traits during pregnancy reveals limited evidence of pregnancy-specific genetic effects

The paper conducts a multi-ancestry, trans-generational GWAS meta-analysis of gestational diabetes and glycemic traits, identifying novel loci and highlighting limited pregnancy-specific genetic effects.

Genetic, intrinsic, and environmental determinants of innate immune cytokine responses in healthy four-year-old children

This study identifies genetic, intrinsic, and environmental factors influencing innate immune cytokine responses in four-year-old children, finding strong genetic and inflammatory biomarker associations.

Utilising novel Mendelian randomization approaches to investigate a potential causal effect of fetal growth on maternal cardiometabolic risk in the UK Biobank

This study uses Mendelian randomization to examine if fetal growth affects maternal cardiometabolic risk, finding no strong causal evidence.

Utilising offspring genotype by proxy Mendelian randomization to investigate the causal effect of offspring traits on parental health

This paper introduces an MR framework to estimate causal effects of offspring traits on parental health using parental genotypes as proxies for offspring genotypes.

Genome-wide analyses identify 21 infertility loci and over 400 reproductive hormone loci across the allele frequency spectrum

This study identifies 21 infertility loci and over 400 reproductive hormone loci through GWAS across multiple cohorts, finding limited genetic correlation between reproductive hormones and infertility.

Genome-wide association analysis of composite sleep health scores in 413,904 individuals

This study performs genome-wide association analysis on composite sleep health scores, identifying 28 novel loci and confirming 341 previously reported loci, with insights into genetic mechanisms and pathways.

A framework for conducting time-varying genome-wide association studies: An application to body mass index across childhood in six multiethnic cohorts

The paper introduces a framework for time-varying GWAS to identify age-varying genetic effects on BMI across childhood, finding 28 genome-wide significant variants, including a novel one in DAOA.

Genome-wide association study of placental weight in 179,025 children and parents reveals distinct and shared genetic influences between placental and fetal growth

This study identifies 40 genetic loci associated with placental weight using GWAS in 179,025 children and parents, revealing shared and distinct genetic influences with fetal growth.

Genetic effects on the timing of parturition and links to fetal birth weight

This study identifies genetic loci associated with gestational duration and preterm delivery, showing maternal and fetal genetic effects and antagonistic pleiotropy with birth weight.

The Genetic Risk of Gestational Diabetes in South Asian women

This study finds that a type 2 diabetes polygenic risk score is strongly associated with gestational diabetes-related traits in South Asian women, accounting for a significant portion of the population attributable fraction.

Investigating a possible causal relationship between maternal serum urate concentrations and offspring birthweight: A Mendelian randomization study

This paper uses Mendelian randomization to investigate the causal relationship between maternal serum urate and offspring birthweight, finding a weaker causal effect compared to observational studies.

Interrogating the causal effects of maternal circulating CRP on gestational duration and birth weight

This study uses Mendelian Randomization to show that higher maternal CRP levels causally reduce gestational duration and birth weight, with some effect mediated through gestational age.

DNA co-methylation has a stable structure and is related to specific aspects of genome regulation

The paper investigates the stability and regulatory implications of DNA co-methylation across age and ancestry, finding stable patterns and links to transcription factor binding and chromatin interactions.

Genome-wide association study meta-analysis identifies three novel loci for circulating anti-Müllerian hormone levels in women

metaboprep: an R package for pre-analysis data description and processing.

metaboprep provides an R package for standardized pre-analysis processing and reporting of metabolomics data, enabling quality assessment and sample/metabolite selection.

Fetal alleles predisposing to metabolically favourable adiposity are associated with higher birth weight

The paper examines the effect of fetal genetic predispositions to metabolically favourable adult adiposity and BMI on birth weight and other anthropometric traits, finding stronger associations with birth weight for the adiposity alleles.

Validation of lipid-related therapeutic targets for coronary heart disease prevention using human genetics

The paper uses Mendelian randomization and clinical/biological evidence to prioritize lipid-modifying drug targets for coronary heart disease prevention.

Higher maternal adiposity reduces offspring birth weight if associated with a metabolically favourable profile

This study uses Mendelian Randomisation to show that maternal metabolically favourable adiposity is associated with lower offspring birth weight compared to general adiposity indexed by BMI.

Genomic and phenomic insights from an atlas of genetic effects on DNA methylation

The paper identifies genetic variants influencing DNA methylation in blood and shows their associations with complex traits and diseases, but finds limited direct causality.

Within-sibship GWAS improve estimates of direct genetic effects

In 159,701 siblings from 17 cohorts, population GWAS overstate direct effects on height, education, smoking, cognition, depressive symptoms and age at first birth; clinical traits mostly agree across models.

Bias in two-sample Mendelian randomization when using heritable covariable-adjusted summary associations

This paper shows that using covariable-adjusted summary associations in two-sample Mendelian randomization can introduce bias, especially when there is residual confounding between the covariable and outcome.

Genome-wide association study implicates novel loci and reveals candidate effector genes for longitudinal pediatric bone accrual through variant-to-gene mapping

The paper identifies 40 novel genetic loci associated with longitudinal pediatric bone accrual and identifies candidate effector genes through variant-to-gene mapping and functional validation.

Investigating the causal effect of maternal vitamin B12 and folate levels on offspring birthweight

This study uses Mendelian Randomization to assess the causal effect of maternal vitamin B12 and folate on offspring birthweight, finding a positive causal effect for folate but not for B12.

Haplotype genetic score analysis in 10,734 mother/infant pairs reveals complex maternal and fetal genetic effects underlying the associations between maternal phenotypes, birth outcomes and adult phenotypes

The paper uses haplotype genetic scores in mother/infant pairs to show maternal and fetal genetic effects influence gestational duration, birth outcomes, and adult phenotypes.

Genome-wide association studies identify 137 loci for DNA methylation biomarkers of ageing

This study identifies 137 genome-wide significant loci associated with DNA methylation biomarkers of ageing using DNAm and SNP data from over 41,000 individuals.

Deep phenotyping of a healthy human HAO1 knockout informs therapeutic development for primary hyperoxaluria type 1.

The paper identifies a healthy individual with complete HAO1 knockout, showing normal oxalate levels but elevated glycolate, supporting the safety of HAO1 inhibition for PH1 therapy.

The Parkinsons Disease Mendelian Randomization Research Portal

This paper applies Mendelian randomization to identify causal factors for Parkinson's disease using 5,839 exposures and reports twelve causal associations, including adiposity.

Genome-wide association analysis of excessive daytime sleepiness identifies 42 loci that suggest phenotypic subgroups

This study identifies 42 genetic loci associated with excessive daytime sleepiness and links them to phenotypic subgroups and related traits.

The genetic architecture of sporadic and recurrent miscarriage

This study identifies genetic variants associated with sporadic and recurrent miscarriage through large-scale association analyses and Mendelian randomization.

GWAS in 446,118 European adults identifies 78 genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates