Jing Chen

The paper introduces a haplotype-based method to estimate maternal and fetal genetic contributions to pregnancy outcomes, finding that gestational duration is mainly influenced by maternal haplotypes while fetal size is influenced by both maternal and paternal haplotypes.

The paper identifies EFNA3 as a factor promoting mammary epithelial collective migration and cancer metastasis by enhancing oxidative phosphorylation.

This study shows mammary epithelial migration occurs without EMT, relying on preserved cell-cell adhesion and Snail1's role in directional movement.

This study identifies 40 genetic loci associated with placental weight using GWAS in 179,025 children and parents, revealing shared and distinct genetic influences with fetal growth.

This study identifies genetic loci associated with gestational duration and preterm delivery, showing maternal and fetal genetic effects and antagonistic pleiotropy with birth weight.

This study uses Mendelian Randomization to show that higher maternal CRP levels causally reduce gestational duration and birth weight, with some effect mediated through gestational age.

The paper uses haplotype genetic scores in mother/infant pairs to show maternal and fetal genetic effects influence gestational duration, birth outcomes, and adult phenotypes.

The paper identifies PP-2, a src-kinase inhibitor, as a novel corrector for ΔF508-CFTR in cystic fibrosis through in silico screening and experimental validation.