Cell BiologybioRxivPreprint
Hidden Structural Bias in Proteomics: Sonication-induced Selective Fragmentation of Intrinsically Disordered Regions
Megumi Narita, Tatsuya Yamakawa, Rika Nishimura, Mio Iwasaki
This study shows sonication causes selective fragmentation of intrinsically disordered proteins in proteomics, leading to structural bias and potential misinterpretation of protein size and stability.
DOI 10.64898/2026.07.14.738389