Author

Kazutoshi Takahashi

Kyoto UniversityORCID 0000-0002-5329-8395Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:CRISPR screen· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Chikako OkuboiD· 2 shared Mari Hamao· 2 shared Michiko NakamuraiD· 2 shared Satoshi SuzukiiD· 2 shared Akira OhtaiD· 1 shared Hirohide SaitoiD· 1 shared Knut WoltjeniD· 1 shared Lu NiiD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCell Biology

Chikako OkuboORCID

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3 papers

Recent·Most cited

EIF3H Sustains Translational Programs Essential for Proliferation in Human Primed Pluripotency

Satoshi Suzuki, Chikako Okubo, Michiko Nakamura, Mari Hamao, Qi Fang, Knut Woltjen, Kazutoshi Takahashi

This study identifies EIF3H as essential for human primed pluripotency by regulating translation of metallothionein genes, impacting proliferation and differentiation.

bioRxiv · May 20, 2026 · PreprintCell Biology

Comparative benchmarking of CRISPRi and CasRx in standardized pluripotent stem cell platforms reveals context-dependent knockdown performance

Lu Ni, Takuya Murakami, Satoshi Suzuki, Mari Hamao, Michiko Nakamura, Chikako Okubo, Kazutoshi Takahashi

This study compares CRISPRi and CasRx for gene knockdown in human pluripotent stem cells, finding CRISPRi provides faster and stronger repression but slower recovery, while CasRx offers reversible knockdown with isoform resolution but lower efficiency.

bioRxiv · May 14, 2026 · PreprintCell Biology

Post-transcriptionally regulated genes are essential for pluripotent stem cell survival

Mio Iwasaki, Yuka Kawahara, Tsuyoshi Tabata, Yohei Nishi, Megumi Narita, Akira Ohta, Hirohide Saito, Takuya Yamamoto, Masato Nakagawa, Shinya Yamanaka, Kazutoshi Takahashi

The paper identifies 20 post-transcriptionally regulated genes essential for pluripotent stem cell survival, showing their protein upregulation and nuclear-to-cytoplasmic mRNA localization.

bioRxiv · Oct 18, 2021 · PreprintMolecular Biology