Author

Michael A. Flinn

Medical College of WisconsinORCID 0000-0002-8200-1693Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cell Biology· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:mouse· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Caitlin Claire O'MearaiD· 3 shared Michaela PattersoniD· 3 shared Alexandra L. PurdyiD· 2 shared Christoph D. RauiD· 2 shared Kaelin A. AkinsiD· 2 shared Samantha K. SwiftiD· 2 shared Abigail Hockett· 1 shared Amirala Bakhshian NikiD· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersCell Biology

Caitlin Claire O'MearaORCID

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintDec 23, 2025

Deletion of the polarity protein Llgl1 impairs cardiomyocyte intercalated disc integrity and permits cell cycle activity into adulthood

Jerrell J. Lovett, Michael A. Flinn, Amirala Bakhshian Nik…·Caitlin Claire O'Meara

This study shows that deleting Llgl1 in cardiomyocytes disrupts intercalated disc integrity, causes electrical conduction defects, and allows cell cycle activity into adulthood, while improving cardiac function after injury.

DOI 10.64898/2025.12.19.695635

mousebulk RNA-seq

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BioinformaticsPLoS GeneticsPeer-reviewedJul 24, 2025

Novel Insights into Post-Myocardial Infarction Cardiac Remodeling through Algorithmic Detection of Cell-Type Composition Shifts

Brian Gural, Logan G. Kirkland, Abigail Hockett…·Christoph D. Rau

The paper develops an algorithm to correct cell-type composition in bulk RNAseq data, revealing novel gene pathways in post-myocardial infarction cardiac remodeling.

5 citations

mousebulk RNA-seq

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Developmental BiologyDevelopmentPeer-reviewedMar 13, 2023

Cardiomyocyte ploidy is dynamic during postnatal development and varies across genetic backgrounds

Samantha K. Swift, Alexandra L. Purdy, Mary E. Kolell…·Michaela Patterson

This study examines cardiomyocyte ploidy dynamics in two mouse strains, revealing differences in developmental progression and identifying new roles for Runx1 and Tnni3k in ploidy regulation.

39 citations

mousebulk RNA-seq

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