Christoph D. Rau

Optimizing Strain Selection for Association Studies Under Hard Cost Constraints

The paper evaluates strain selection methods under cost constraints for association studies, finding that cost-based approaches often outperform diversity-focused ones.

Genetic Determinants of Heart Failure Susceptibility and Response in the Collaborative Cross Mouse Population

The paper identifies genetic loci associated with heart failure susceptibility and response in mice, highlighting candidate genes that modulate cardiac hypertrophy.

A systems genetics approach to uncover mitochondrial drivers of heart failure reveals mitochondria-nuclear cross talk in genetically diverse mouse strains

The paper uses systems genetics in genetically diverse mice to identify mitochondrial-nuclear interactions contributing to heart failure, finding 24 gene candidates associated with mt-DNA and HF.

LocusPackRat: a Semi-Automated Framework for Prioritizing Candidate Genes from Large GWAS Intervals

LocusPackRat streamlines candidate gene prioritization from GWAS intervals by integrating diverse evidence packets, enhancing experimental validation in model organisms.

Global Analyses of Genomic and Epigenomic Influences on Gene Expression Reveals Serpina3n as a Major Regulator of Cardiac Gene Expression in Response to Catecholamine Challenge During Heart Failure

The paper identifies Serpina3n as a major regulator of cardiac gene expression in heart failure by integrating genetic and epigenetic data from mouse strains.

Novel Insights into Post-Myocardial Infarction Cardiac Remodeling through Algorithmic Detection of Cell-Type Composition Shifts

The paper develops an algorithm to correct cell-type composition in bulk RNAseq data, revealing novel gene pathways in post-myocardial infarction cardiac remodeling.

Mapping DNA Methylation to Cardiac Pathologies Induced by Beta-Adrenergic Stimulation in a Large Panel of Mice

This study identifies DNA methylation loci associated with heart failure in mice, showing their functional relevance and therapeutic potential through in vitro and in vivo experiments.

Very long-chain ceramides in muscle associate with insulin resistance independent of obesity

The paper identifies very long-chain ceramides in muscle as independently associated with insulin resistance, separate from adiposity effects, using genetic variation in mice.

Cardiomyocyte ploidy is dynamic during postnatal development and varies across genetic backgrounds

This study examines cardiomyocyte ploidy dynamics in two mouse strains, revealing differences in developmental progression and identifying new roles for Runx1 and Tnni3k in ploidy regulation.

Modeling Epistasis in Mice and Yeast Using the Proportion of Two or More Distinct Genetic Backgrounds: Evidence for "Polygenic Epistasis"

The paper develops a statistical test to detect polygenic epistasis by analyzing genotype-by-ancestry interactions in mice and yeast, finding significant associations across multiple phenotypes.

A personalized, multi-omics approach identifies genes involved in cardiac hypertrophy and heart failure

The paper identifies disease-associated genes missed by traditional methods using a personalized differential gene expression analysis in a genetically diverse mouse model of cardiac hypertrophy and heart failure.