The ERCC6L2-MRI-KU complex coordinates NHEJ at staggered DNA double-strand breaks.
Pia I. Reichl, Ceylan Sönmez, Yueru Sun, Ashleigh King, Jean S. Metson, Benjamin Davies, Adam C. Wilkinson, Francisca Lottersberger, J. Ross Chapman
The paper identifies the ERCC6L2-MRI-KU complex as a KU-regulatory DNA translocase that coordinates NHEJ at staggered DNA double-strand breaks, linking it to immunodeficiency and haematopoietic failure in ERCC6L2 disease.
bioRxiv · Nov 28, 2025 · PreprintMolecular Biology