J. Ross Chapman

ATM safeguards DNA replication at endogenous base lesions

This study identifies how ATM deficiency leads to PARPi sensitivity through replication defects caused by oxidative base damage and impaired fork reversal.

The ERCC6L2-MRI-KU complex coordinates NHEJ at staggered DNA double-strand breaks.

The paper identifies the ERCC6L2-MRI-KU complex as a KU-regulatory DNA translocase that coordinates NHEJ at staggered DNA double-strand breaks, linking it to immunodeficiency and haematopoietic failure in ERCC6L2 disease.

Shieldin and CST co-orchestrate DNA polymerase-dependent tailed-end joining reactions independently of 53BP1-governed repair pathway choice

This study investigates the role of shieldin and CST in DNA end-joining and HR suppression, showing their collaboration in DNA repair and the independence of 53BP1's effects.

BARD1 links histone H2A Lysine-15 ubiquitination to initiation of BRCA1-dependent homologous recombination

This study identifies BARD1's role in recruiting BRCA1 to DNA damage sites via H2AK15ub binding, linking it to HR and pathway choice.

Human PRDM9 Can Bind And Activate Promoters, And Other Zinc-Finger Proteins Associate With Reduced Recombination In cis

The paper investigates PRDM9 binding and its effects on meiotic recombination and gene expression in human cells, finding that DNA-binding motifs and histone modifications predict recombination outcomes.