Adam C. Wilkinson

This study identifies Hoxb5 as a marker for long-term hematopoietic stem cells in fetal liver, showing its utility in purification and revealing developmental regulation.

This study identifies LIN28B as essential for fetal B-lymphopoiesis and KMT2A::AFF1 infant leukemia initiation, showing its role in promoting proliferation and leukemogenesis.

This study identifies that HIF-1 activation by PIM1 in JAK2V617F-MPNs drives non-canonical transcription complex formation and disease progression.

This study uses CRISPR-Cas genome editing to selectively inactivate JAK2 V617F mutations in patient cells, showing that heterozygous cells are not oncogene addicted while homozygous cells are eradicated, suggesting genome editing as a potential treatment for MPNs.

The paper identifies the ERCC6L2-MRI-KU complex as a KU-regulatory DNA translocase that coordinates NHEJ at staggered DNA double-strand breaks, linking it to immunodeficiency and haematopoietic failure in ERCC6L2 disease.

This study develops a polymer-based culture system to expand human haematopoietic stem and progenitor cells while preserving age-related transcriptional programs, enabling research on ageing haematopoiesis.

This study develops iPSC-derived T cells targeting the EGFR C797S mutation in NSCLC, showing their ability to recognize and kill cancer cells expressing this mutation.

This study shows that inhibiting MLLT1 selectively limits MLL-AF4-driven leukemia growth without harming healthy hematopoietic stem cells.

This study shows reducing oxidative stress enhances ex vivo growth of human haematopoietic stem and progenitor cells in polymer-based cultures and enables efficient gene editing.

This study uses in vivo CRISPR screening to identify SAGA complex members as key regulators of hematopoiesis, showing their loss impairs blood production and activates interferon pathways.

This study corrects the beta-globin gene in sickle cell disease patient-derived HSCs using CRISPR/Cas9 and shows improved in vivo erythropoiesis in a mouse model.

This paper develops a droplet digital PCR assay to quantify chimerism in mouse tissues, showing it is robust, minimally biased, and compatible with crude lysates.

This paper establishes expanded potential stem cells (EPSCs) from mouse blastomeres and shows they can contribute to both embryo proper and trophoblasts in chimeras.