Ashleigh King

This study identifies how ATM deficiency leads to PARPi sensitivity through replication defects caused by oxidative base damage and impaired fork reversal.

The paper identifies the ERCC6L2-MRI-KU complex as a KU-regulatory DNA translocase that coordinates NHEJ at staggered DNA double-strand breaks, linking it to immunodeficiency and haematopoietic failure in ERCC6L2 disease.

This study investigates the role of shieldin and CST in DNA end-joining and HR suppression, showing their collaboration in DNA repair and the independence of 53BP1's effects.